RESUMEN
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a rare disorder associated with increased mortality and morbidity. There are currently two drugs approved for IPF but their safety and efficacy profile in real-world settings in Spain is not well understood. METHODS: An observational, multicentre, prospective study was carried out among patients with IPF who started treatment with pirfenidone or nintedanib from 2015 to 2021. Data regarding clinical characteristics, drug adherence, safety profiles and clinical outcomes between these two drugs were collected. RESULTS: 232 patients were included in the analysis. There were no meaningful differences between both groups at baseline. Patients who started pirfenidone showed a decreased risk for treatment withdrawal compared with those starting nintedanib (HR 0.65 (95% CI 0.46 to 0.94; p=0.002)). Time to first adverse event and all-cause mortality was similar between study groups. Risk factors for withdrawal were female sex, diarrhoea and photosensitivity. CONCLUSIONS: in this real-world study, both pirfenidone and nintedanib showed similar efficacy profiles. Pirfenidone was associated with less treatment discontinuations due to side effects.
Asunto(s)
Fibrosis Pulmonar Idiopática , Indoles , Piridonas , Humanos , Fibrosis Pulmonar Idiopática/tratamiento farmacológico , Fibrosis Pulmonar Idiopática/mortalidad , Femenino , Masculino , España , Piridonas/uso terapéutico , Piridonas/efectos adversos , Estudios Prospectivos , Anciano , Indoles/uso terapéutico , Indoles/efectos adversos , Resultado del Tratamiento , Persona de Mediana Edad , Antifibróticos/uso terapéutico , Cumplimiento de la Medicación/estadística & datos numéricos , Anciano de 80 o más AñosRESUMEN
No disponible
Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Sarcoma de Parte Blanda Alveolar/patología , Neoplasias Pulmonares/patología , Sarcoma de Parte Blanda Alveolar/diagnóstico por imagen , Hemoptisis/complicaciones , Disnea , Pérdida de Peso , Tomografía Computarizada por Rayos X , Broncoscopía , Tomografía de Emisión de Positrones , BiopsiaRESUMEN
No disponible
Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Granuloma de Células Plasmáticas del Pulmón/diagnóstico por imagen , Granuloma de Células Plasmáticas del Pulmón/tratamiento farmacológico , Fibrosis Pulmonar/diagnóstico , Fumadores , Hipotiroidismo/complicaciones , Biopsia con Aguja/métodos , Granuloma de Células Plasmáticas del Pulmón/complicaciones , Biomarcadores de Tumor , Carcinoma de Células Escamosas/patología , Corticoesteroides/uso terapéuticoRESUMEN
No disponible
